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In various experimental models, glutamine administration has been shown to reduce epithelial cell death and preserve or improve barrier function.[11-13] For instance, in an animal model of chemotherapy-induced intestinal damage, glutamine decreased the severity of intestinal injury perhaps through improved intestinal cell turnover and enhanced antioxidant activity.*[14] Muscle Tissue Preservation Of the 20 amino acids required for protein synthesis, glutamine is the most abundant

10.1073/pnas.89.18.8641 118 ThuleP

Research has demonstrated that augmented glutamine metabolism in CAFs gives rise to collagen-rich extracellular matrix and fosters tumor development [134, 135]

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