Additionally, you may confirm whether a product is unregistered and subject to an advisory by accessing the FDA Advisories Issuances Database at
There are several theories as to the key immunologic players in their development, along with continued debate over whether its the parent drug or a metabolite that results in immune cell activation
PLoS ONE 8 , e54429 (2013)
For example, in a 30-day randomized, double-blind, placebo-controlled study (with an additional 30-day open-label extension), subjects taking 60 milligrams of a standardized ashwagandha root and leaf extract experienced significant increases in immune markers, including immunoglobulins (IgA, IgM, IgG), cytokines such as interferon- and interleukin-4, and various white blood cell subsets like T cells (CD3+, CD4+, CD8+), B cells (CD19+) and natural killer (NK) cells, compared with placebo