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7 Loss of SLC25A39/40 decreases the steady state levels of iron-sulfur containing proteins and phenocopies iron-sulfur cluster deficiency

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Recent structural studies using cryo-electron microscopy (cryo-EM) have elucidated the structure of the DDD or DDD-Ube2e2 complex, with one report further showing that the assembly and function of CRL4 DET1-COP1 require a network of specific and flexible interactions-DET1 recruits Ube2e family E2s, DDA1 stabilizes DET1 and enables COP1 recruitment, and these coordinated interactions allow the assembly of the functional ligase complex 23,24

Interestingly, and perhaps more importantly, mice carrying the L973F- IR also showed a decrease in weight gain and reduced size of Sub-WAT following challenge with HFD