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From an aesthetic perspective, this matters because: GLP-1 RAs influence body composition, reducing lean mass, which might alter diffusion or uptake of injectables They impact systemic metabolism which may alter the pharmacokinetics or pharmacodynamics of other drugs As more patients on GLP-1 therapy request cosmetic injectables, including botulinum toxin, the potential for interaction becomes clinically relevant

Instead of focusing solely on the mechanical aspects of joint problems, it recognizes the importance of overall metabolic health in patients surgical and long-term outcomes

Another consideration is the effect on weight and appetite

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