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Description

If recommended dose is exceeded the production of NAPQI increases, but the ability of the liver to synthesise the inactivating glutathione cannot keep pace, and NAPQI accumulates in liver cells, disrupting cellular mechanisms and eventually causing liver cell death (necrosis) 8

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Hypoxia modulates the purine salvage pathway and decreases red blood cell and supernatant levels of hypoxanthine during refrigerated storage

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