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This increase is associated with depletion of bicarbonate stores to almost zero 55 , which may contribute to the transition of ketonemia to an unfavorable condition for the body called the state of ketoacidosis

Managing Side Effects in Research Settings Strategies that have proven effective in clinical trials for managing cagrilintide-related side effects include: Slower titration schedules Extending time between dose increases Meal timing adjustments Taking doses after meals rather than before Hydration optimization Maintaining adequate fluid intake Dietary modifications Smaller, more frequent meals

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Funding This work has been supported by the National Natural Science Foundation of China (No