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Berberine is not recommended during pregnancy due to potential risks to the fetus and concerns about neonatal jaundice from displacement of bilirubin, which could lead to kernicterus

AHK-Cu targets the follicular environment through peptide signaling while minoxidil handles blood flow through vasodilation

Conversely, animal models have also established that low levels of histamine-induced depression-like behavior, decreased locomotor activity in the home cage, and impaired aversive memory, leading to a decrease in wakefulness as well [185]

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