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The ongoing CVOT of tirzepatide (SURPASS-CVOT, NCT04255433) will compare tirzepatide with dulaglutide 1.5 mg/wk to determine efficacy for the primary outcome of 3-point MACE [70]

This research is branching into: Cardiovascular health Kidney disease prevention Neurodegenerative protection (Alzheimers/Parkinsons) Metabolic health is becoming the "hub" of the pharmaceutical industry

Regulatory considerations, challenges and risk-based approach in nanomedicine development

In another experiment with a similar model, exenatide injections into the spinal area decreased responses to heat and touch by increasing the spinal release of -endorphins, IL-10, and IL-4, associated with reduced pain perception [98,99]