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For example, zileuton (226), red-kerneled rice proanthocyanidin (227), malabaricone C (228), caffeic acid (89), lysionotin (229) and magnolin (230) inhibit AA lipoxygenase by inhibiting the expression of key enzymes or enzyme activity reduction to achieve the anti-inflammatory effects (231236), the specific drugs used are shown in Table 6

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When insulin binds to the -subunits, it activates the intrinsic kinase activity of the -subunits, leading to auto-phosphorylation of tyrosine residues in the receptors intracellular domain (41)