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Fase I: se lleva a cabo en un pequeo nmero de voluntarios sanos o pacientes muy enfermos que carecen de opciones de tratamiento, y est diseada para estudiar los efectos del medicamento en el cuerpo humano

doi: 10.3390/ijms20236024 [DOI] [PMC free article] [PubMed] [Google Scholar] 170

2.4.2 TRAPP calculations and extraction of active site conformations from 500 ns MD simulations The RMSF values for heavy atoms (backbone and side chain) were calculated for active site residues, key pocket (refer to Section 2.1.2)

Corticosteroid injection can be performed in chronic or persistent bursitis after a trial of more conservative therapy