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Caffeine , due to its vasocontrictive properties, is sometimes combined with aspirin and/or acetaminophen as well (Aukerman 2002)

On the other hand, a study in vitro explored the effect of EGT on rat vascular reactivity, and it was concluded that EGT could protect nitric oxide from damage and maintain its activity by reducing superoxide anions ( 2.2 Ischemia-Reperfusion Injury Ischemia-reperfusion (IR) injury triggers the massive production and accumulation of ROS and oxidative stress-mediated injury, which occurs in almost all organs, such as the heart, liver, and intestines (Zhou et al., 2018

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Lpez-Lpez, L