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Peripheral IR primarily involves reduced insulin-mediated glucose uptake by skeletal muscle and adipose tissue, driven by defects in the insulin receptor substrate and downstream signaling pathways such as phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt), leading to diminished translocation of glucose transporter type 4 (SLC2A4/GLUT4) and glucose uptake [5]

However, be careful with your diet as a steady diet of canned tuna-fish or tuna sushi is actually enough to cause methylmercury build-up with effects on the gut and other organs

Iron exists in two dietary forms: Haem iron (from meat, poultry, fish) more readily absorbed Non-haem iron (from plant sources, fortified foods) less efficiently absorbed Patients on Wegovy who significantly reduce their overall food intake or adopt restrictive eating patterns may struggle to meet these requirements