Inflammaging plays a critical role in the pathogenesis of diabetes and the destruction of pancreatic cells as well
Introduction Dopaminergic neurons, that project to many central nervous system (CNS) areas, have been implicated in a myriad of neurologic diseases including Parkinson's disease, dementia with Lewy bodies and Alzheimer's disease, which are all caused by neurodegeneration (Piggott et al., Experimental Facts: Dopaminergic Synapse In catecholaminergic neurons dopamine is synthesized in the cytosol near the synaptic vesicle (Cartier et al., Experimental Facts: Spontaneous Dopamine Oxidation Dopamine autoxidation occurs in an aqueous solution without enzymes such as MAO, catechol-O-methyltransferases (COMT) or diamine oxidases (DAO)
Importantly, stem cells have been shown to improve memory and reduce inflammation in Alzheimers animal models (4c) (4d), and patients' own MSCs can safely be harvested and prepared for many specific applications with substantial evidence of good safety and effectiveness, with increasing evidence that they can help neural tissue repair, and we continue to investigate their unique benefits in the treatment of ischemic stroke, traumatic neural injury, and neuroregenerative tissue repair (4e) (4f)
NAION is fundamentally an optic nerve perfusion problem
