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People who eat a plant based diet, older adults, and anyone with certain digestive conditions are more likely to run low

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To emphasize the importance of the oxidative stress as the main mechanism of pravastatin side effect, we supplemented mice diet with another mevalonate pathway independent antioxidant, creatine, which was recently shown to protect against muscle mitochondrial oxidative damage induced by pravastatin ( Figures 2E,F show that creatine diet supplementation also significantly decreased H 2 O 2 production and restored aconitase activity that were altered by pravastatin treatment ( Figure 3 )