The lists of upregulated and downregulated proteins were submitted to the Database for Annotation, Visualization, and Integrated Discovery (DAVID) v6.7 and mapped to KEGG pathways
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3.3.1 Autologous chondrocyte implantation (ACI) ACI is a cell-based surgical technique designed to repair focal articular cartilage defects, particularly in the knee, to restore hyaline-like cartilage and delay OA progression
Mechanistically, alterations in gut microbial metabolites such as SCFAs could affect the integrity of the BBB, induce systemic endotoxemia, and activate microglia so as to impact disease progression