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Moreover, glutamine-induced activation of mTORC1 results in the phosphorylation of the enzyme complex called carbamoyl phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (CAD), which catalyzes the condensation reaction converting glutamine-derived nitrogen into the pyrimidine precursor orotate 34,35

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By week 24, hunger reductions reached approximately 15-16 points versus placebo, and dietary restraint increased by 2.0 points, indicating not just reduced hunger but improved ability to consciously manage food intake