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Exogenous sources of free radicals include environmental factors such as ultraviolet (UV) radiation, ionizing radiation, tobacco smoke, pollution, and exposure to certain chemicals and drugs [24]

Additionally, noise exposure and cochlear ablation upregulate BDNF expression in the inferior colliculus alongside GAD65 (glutamate decarboxylase), suggesting that BDNF participates in the excitatory/inhibitory balance within central auditory structures following acoustic insult (Erol et al., 2012)

Experiments in animals with uniformly labeled 13C-glutamine demonstrated that glutathione was enriched with five 13C atoms, indicating that glutamine is the primary source for glutathione synthesis [11]

The reconstitution process is identical for both