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These biochemical alterations could provide a direct measure of disease onset or severity, for example

Mutations in SLC19A2 cause thiamine-responsive megaloblastic anaemia associated with diabetes mellitus and deafness

The Pharmacologic Approaches to Glycemic Management section contains changes that align it with the ADA and the European Association for the Study of Diabetes (EASD) consensus statement published in 2022 and featured in a previous Diabetes Pharmacy Newsletter