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Long-Term Benefits Enhanced Insulin Sensitivity : Over time, GLP-1 helps improve insulin sensitivity, which leads to better glucose control and reduced long-term complications of diabetes

Some reasons patients consider deprescription include: Negative side effects Cost and coverage challenges Difficulty adhering to treatment Reaching their health goals Hitting a weight-loss plateau Preference not to remain on medication long term Without a comprehensive lifestyle and nutrition plan, many patients who stop GLP-1s regain the weight they lost

Subchondral bone loss and advanced osteosclerosis are important pathological alterations in OA [92]

Haglund, M