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doi: 10.3389/fimmu.2021.701282 77 HeYHaraHNezG

Another mechanism by which the endo/lysosomal compartment can influence APAP-induced hepatotoxicity is through the clearance of damaged mitochondria in a process also called mitophagy, consisting in the degradation of dysfunctional mitochondria by lysosomal proteases upon fusion of the autophagosomes-containing mitochondria with lysosomes, which is discussed in the next section

Concurrently, it reduces the amount of glucagon released by the pancreas, a hormone that signals the liver to release stored sugar into the bloodstream