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Key Points Your body takes about 5 weeks to completely eliminate semaglutide after your last dose, with effects gradually wearing off during this period Clinical studies show people typically regain two-thirds of their lost weight when they stop taking semaglutide medication Work with your healthcare provider to gradually reduce doses instead of an abrupt stop A nutritious diet and exercise can help you manage semaglutide withdrawal symptoms Your body adapts to semaglutide over time, creating changes that don't simply reverse when you stop

Pratley R, Amod A, Hoff ST, Kadowaki T, Lingvay I, Nauck M, Pedersen KB, Saugstrup T, Meier JJ., PIONEER 4 investigators