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Enhancing GSH, mainly through NAC, GSH precursors or pro-GSH compound administration, becomes a potential treatment option for SARS-CoV-2 infection and COVID-19 disease by reducing oxidative stress and cytokine expression especially in diabetic patients at risk of more severe disease (Singh et al., 2022)

A landmark 2024 study published in the Proceedings of the National Academy of Sciences (PNAS) by researchers at Stanford University directly compared the bioenergetics of immune cells in ME/CFS and Long COVID patients

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28 However, small molecules also face a higher risk of 9-year IRA negotiations, leading to a strategic tension between ease of administration and longevity of premium pricing