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In PCOS, where OS and IR intersect, MI supplementation restores downstream insulin sensitivity while attenuating ROS generation, a dual action that integrates metabolic correction with redox stabilization ( Experimental and clinical studies collectively reveal that MI modulates cellular redox balance by enhancing antioxidant enzyme activities and reducing oxidative biomarkers such as malondialdehyde (MDA) and nitric oxide derivatives (146, 149, 151)