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Description

Moreover, IGF-IR has kinase-independent functions, such as nuclear translocation and regulation of gene expression, and interaction with SGLT1 to maintain intracellular glucose levels [209]

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By altering histone acetylation and DNA methylation patterns, these dietary compounds can modify chromatin structure and influence the expression of genes involved in stress resistance, inflammation, and longevity, thereby conferring a durable adaptive advantage

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[1] As expected, age significantly affected the levels of all neuromodulators, with young animals exhibiting higher levels than older ones

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