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GLP-1RAs have also been shown to attenuate vascular inflammation and oxidative stress, while preserving endothelial barrier integrity and limiting neutrophil infiltration in models of sepsis-associated acute lung injury (ALI) (Helmstadter et al., 2021

The branded version, Mounjaro, comes in single-use auto-injector pens at fixed doses

Constipation is also common, resulting from the combined effects of the following: age-related slowing of gastrointestinal transit lower fluid intake reduced physical activity GLP-1-induced delayed gastric emptying Increasing soluble fiber intake through foods such as oats, legumes, chia seeds, fruit, or psyllium supplementation may help promote bowel regularity, but fiber should be increased gradually and paired with adequate hydration to avoid worsening symptoms

Arch Emerg Med Crit Care