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Compounders across the United States, who had stepped up to fulfill the Ozempic orders during the shortage, are suing the FDA for allegedly bypassing the required notice and comment period before taking this step

This matched-dosing approach maintains the pulsatile GH-release pattern that more closely mimics natural physiology in research models

doi: 10.1016/j.phymed.2025.156438 201 AthapaththuALeeKTKavindaMHDLeeSKangSLeeMHet al

By engaging GLP-1 Rs across the gut-brain axis, these agents potentiate physiological satiety signals, slowing gastric emptying, suppressing hunger cues, and diminishing the hedonic appeal of calorie-dense foods