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PD-1/L1 inhibitor therapy also increases the risk for reactivation compared with CLTA-4 inhibitor therapy

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Upon activation, calcineurin dephosphorylates and stimulates TFEB, which in turn translocates into the nucleus where it binds to the coordinated lysosomal expression and regulation (CLEAR) sequence to upregulate expression of several genes involved in the autophagic pathway (Tong and Song, 2015

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