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Studies have characterised MC1R-mediated anti-inflammatory signalling in macrophage and neutrophil models , examining cAMP-mediated NF-B suppression and cytokine production inhibition and and have examined MT-1s effects in inflammatory bowel disease, arthritis, and ischaemia-reperfusion injury models where melanocortin anti-inflammatory biology has been characterised

Diaz, F

[7] Experimental psychometric studies using double-blind crossover designs confirm measurable decrements in sustained attention and reaction time within 0.5-3.5 h after intravenous administration of 50 mg, correlating with cortical H receptor occupancy

LCCN 72088328 Smiley A, McGuire J