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And in the brain, it crosses the blood-brain barrier and activates anorexigenic neurons in the hypothalamus, specifically the POMC/CART pathways that signal fullness while suppressing the NPY/AgRP pathways that drive hunger

2.6.1 Altering the nutrient supply within the TME The nutrient supply within the TME ( Figure 1A ) can be changed by drugs, which modify tumor cell metabolism or alternatively by dietary changes ( Figures 1B, C )

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Healthy nutrition, movement, hydration, and lifestyle habits are encouraged to help optimize long-term results