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Role in Weight Loss: B vitamins are especially important during caloric restriction, as low intake can lead to fatigue and slow metabolic progress

Potential risks include breast tenderness, headaches, slight increase in breast cancer risk with prolonged synthetic progestin use (not seen with micronized progesterone), blood clot risk with oral estrogen (not transdermal), and gallbladder disease risk with oral estrogen

In the early stages of CKD, there is evidence of elevated oxidative stress, which is linked to the progression to end-stage renal disease