Diabetes Obes Metab 2022;24(2):212220
Phosphodiesterase-5 (PDE5) inhibitors such as sildenafil are often effective first-line treatments and are generally safe to use alongside GLP-1 medications, though they are contraindicated with nitrate medications and riociguat, and should be used with caution in unstable cardiovascular disease or if taking alpha-blockers
[DOI] [PubMed] [Google Scholar] 66.Dieterich I.A., Lawton A.J., Peng Y., Yu Q., Rhoads T.W., Overmyer K.A., Cui Y., Armstrong E.A., Howell P.R., Burhans M.S., et al
Precision Engineered Retatrutide is an investigational triple-agonist peptide targeting GIP, GLP-1, and glucagon receptors, studied for metabolic regulation, energy expenditure, and body composition research