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For many people, those early symptoms are part of a bigger adjustment period described in our weight loss biology article

As chronic PE induces tissue changes that go beyond skeletal muscle tissue (e.g., increase in mitochondria in adipose tissue), it is plausible that changes such as improvement in mitochondrial metabolism (improves their structure and function) in the epidermis also could occur in response to physical training practice (see Figure 6)

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For individuals living with these overlapping conditions, addressing metabolic health may reduce some of the inflammation and hormonal imbalance that worsens endo symptoms