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They exert toxic effects by inhibiting acetylcholinesterase (AChE) activity in the nervous system, leading to the interruption of respiration and neuromuscular transmission [158]

He also points to late-phase trials showing up to 22.7 percent weight loss when a different amylin-based drug in development (cagrilintide) is used in combination with a GLP-1 (semaglutide)

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