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The time of bolus injection may be adapted to the actual time of the start of intake, and the rapid-acting insulin dose may also be adapted to the composition of each meal.15 Premixed insulinsIntroduction Premixed insulins are a fixed combination of an intermediate-acting insulin with regular insulin or with a rapid-acting analogue.19,20 They are usually administered twice daily, before breakfast and supper, but may be administered at the three main meals

Allergy symptoms are usually reduced at night due to circadian suppression of mast cell activation.[ref] However, allergens combined with disruption of circadian rhythm could alter histamine levels at night

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