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Blood (2008) 111(7):37519.10.1182/blood-2007-07-102186 93 GorantlaSPDechowTNGrundlerRIllertALZum BuschenfeldeCMKremerMet alOncogenic JAK2V617F requires an intact SH2-like domain for constitutive activation and induction of a myeloproliferative disease in mice

Key things to check: Vial integrity no cracks, proper seal, cap intact Powder appearance should be a solid cake or loose powder, NOT liquid Labeling batch/lot number, milligram content, "for research use only" Cold pack reputable vendors ship with cold packs in summer months Storage Guidelines Key point: Keep unreconstituted vials refrigerated and only mix what you'll use within 28 days

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