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Potential complementary evidence of GLP-1RAs and SGLT2is In a meta-analysis comparing the effects of GLP-1RAs with SGLT2is, five GLP-1RA (ELIXA, LEADER, SUSTAIN-6, EXSCEL, and Harmony Outcomes) and three SGLT2i trials (EMPA-REG OUTCOME, CANVAS Program, and DECLARE-TIMI 58) with a total of 77,242 patients were include [35]

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Their study demonstrated that VPA and TSA treatment after oxygen and glucose deprivation led to re-oxygenation in rat cortical neurons, promoted neuronal regeneration and neuronal protection through upregulation of BDNF expression