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Evidence also suggests that CB 2 Rs are present on post-synaptic terminals of neurons in rodents and non-human primates, although expression levels are relatively low and may depend on brain region (Brusco et al., 2008

The benefit holds across populations: in women of reproductive age , six months of 600 mg myo-inositol and 83 mcg selenium improved TSH, autoimmunity markers and ultrasound, and eased symptoms such as fatigue, weight changes and cold intolerance (Payer et al., 2022), with possible prevention of subclinical hypothyroidism in pregnancy (Porcaro and Angelozzi, 2018)