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This paper represents a major part of my PhD and postdoctoral research where we explored strategies for glutathione-responsive and PSMA-dependent delivery of PROTAC prodrugs for prostate cancer

Results Anti-nitrative effect of trisulfides as an introductory part of the study Given the potent anti-oxidative functions of GSSSG and LASSS, the first set of experiments was designed to examine if these trisulfides have potential to prevent peroxynitrite-induced nitration-dysfunction of HGF by ECL-Western blotting (see Figure 1a for the in vitro experimental design)

The final map was postprocessed by DeepEMhancer 61

Reality : Loses significant potency within hours to days