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Generation of the metabolic models of Fh1 / and Fh1 fl/fl cells / fl/fl To investigate the metabolic changes that occur due to FH-inactivation metabolic models of Fh1 / and Fh1 fl/fl , cell lines were constructed based on their transcriptomics and uptake-secretion metabolomics

Toxicity is not a concern with standard cosmetic doses

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The pharmacokinetic properties including intestinal permeability, first-pass metabolism, microbiota-mediated biotransformation, plasma half-life, and systemic availability is essential for translational relevance