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Increased lean body mass: while not a muscle-building peptide in the traditional sense, tesamorelins effect on GH levels supports lean mass preservation, which is clinically significant for patients over 50

However, with exogenous GLP-1 RAs, active levels of GLP-1 RAs can rise to 10-30 times the normal physiological levels (depending on the agent used) and maintain steadily high levels independent of meal ingestion

The competition Lillys rival oral drug, orforglipron, won FDA approval in April 2026 and is now available in the US

Similarly, apart from the two patients, the dietitian and a couple of doctors, most workgroup members do have disclosures (see page 101 onwards of main document) to companies whose products are being discussed below