glp-1+gip Major physiological roles of GLP-1 and GIP. Tirzepatide is acting as an GLP-1 Receptor Agonists | New

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Large trials show fewer heart attacks and strokes with GLP-1 use through improved endothelial function, reduced oxidative stress, and better nitric oxide availability. If other benefits manifest at lower doses, cardiovascular protection likely does too

In current UCED patient treatment regimens, the effect of volume expansion is even fortified with the use of hypertonic dextrose 10% solution (15 ml/kg/h) during the two-hour bolus injection of SB + SPA 1,7

While SGLT2-i and GLP-1RA may offer additive or synergistic benefits in reducing BP and cardiovascular risk, current guidelines do not support their role as first-line antihypertensive agents or early adjunctive therapies over established agents such as thiazide diuretics, renin-angiotensin system (RAS) inhibitors, or calcium channel blockers (CCBs)