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If you need to stop taking your beta-blocker for whatever reason, let your doctor know so you can come up with a plan together for cutting back your use slowly to give your body necessary time to adjust

Conversely, in a randomized controlled trial involving adults with T2DM, administration of liraglutide for 26 weeks in addition to standard therapy with insulin, although significantly decreased body weight and levels of glycated hemoglobin HbA1c in patients, but at the same time failed to reduce Becks Depression Inventory (BDI) scores (de Witt 2014)

Most practitioners recommend 12-16 week cycles followed by a 2-4 week assessment break