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doi: 10.1016/j.jpeds.2004.06.045 66 NowaczykMJWayeJSDouketisJD

PLoS One (2013) 8(5):e63626.10.1371/journal.pone.0063626 129 Fukuda-TsuruSKakimotoTUtsumiHKiuchiSIshiiS

The underlying mechanism involves nitric oxide synthesis and FAK/paxillin cytoskeletal signaling

In rodents, CYP induction decreases ITZ-associated hepatotoxicity while CYP inhibition increases toxicity, so either the parent compound or metabolites produced by an alternative pathway likely cause toxicity (32, 40)