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The sources of uncertainty include how plants perceive changes in light intensity, the cellular signaling pathways that mediate communication between the nucleus and organelles (including signals that alter photosynthetic systems to dissipate/rebalance excess excitation energy), as well as plastid-to-nucleus retrograde stress responses

Although GPX4 is the primary mechanism for inhibiting iron poisoning, studies have shown that cells deficient in GPX4 can still survive in the activated state of ferroptosis

Feb 21 2021;13(2)doi:10.3390/nu13020684 Sohaei S, Amani R, Tarrahi MJ, Ghasemi-Tehrani H

Microrna-137 regulates hypoxia-induced retinal ganglion cell apoptosis through notch1