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34,35 However, the controversy surrounding the possible benefits of GIPR agonism stems from two main observations: its impaired insulinotropic effects, 36,37 and the prevention of weight gain by suppression of endogenous GIP-induced adipogenesis, 38,39 However, these seemingly discouraging observations have been questioned by the finding of the central anorexic effects of GIP, 4042 and benefits of the GLP-1R/GIPR dual agonist LY3298176 (tirzepatide) in diabetic and overweight individuals

Hum Exp Toxicol

Together, these findings highlight histone crotonylation as a stress-sensitive epigenetic mechanism that regulates synaptic plasticity and depressive-like behaviors, primarily via CDYLEZH2VGF signaling