semaglutide and hfpef Potential action mechanisms of in the phenotype of heart Design and Baseline Characteristics of

2 This means the medication may not work effectively, may cause serious health problems or in some cases may be life-threatening

One study found that semaglutide reduced body weight by around 15% after over a year

Acknowledgements We are thankful for the support from the National Key Research and Development Program of China (2025YFE0107400), National Natural Science Foundation of China (82341232, China), the Future Network (083GJHZ2023012FN), and Grand Challenges (083GJHZ2023021GC) of the International Partnership Program of the Chinese Academy of Sciences, CAS Presidents International Fellowship Initiative (2024VBB0004), Overseas Base Project of CAS, and High-level Innovative Research Institute (2021B0909050003), and Zhongshan Municipal Bureau of Science and Technology (LJ2021001)

The propensity score for receiving ALCAR treatment was calculated in subjects treated with 3 g/day and not treated, and, separately, in those treated with 1.5 g/day and not treated