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These regions process satiety signals from the gut and produce the "I've had enough" feeling during and after meals

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This was first suggested for the GLP-1R agonists exendin-4 and liraglutide when it was shown that the suppression of food intake that they cause upon systemic administration is prevented or attenuated when the GLP-1R antagonist exendin-9 is centrally administered in rats [7] and when central GLP-1Rs are deleted in mice [8]