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2 Although the pancreatic effects of GLP-1 (glucose-dependent insulin secretion and glucagon suppression) are well-established, its extrapancreatic actions are increasingly being recognised as critical to the therapeutic effects of GLP-1RAs

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Its primary function is in tissue repair: it promotes actin polymerization (required for cell movement), upregulates anti-inflammatory proteins, and stimulates the migration of keratinocytes and endothelial cells that are needed to close and repair damaged tissue

Su accin principal se centra en la estimulacin de la secrecin de insulina dependiente de glucosa, la inhibicin de la secrecin de glucagn y la disminucin del vaciado gstrico