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Share GLP-1, GIP, Amylin & Glucagon What Really Drives Results

New @Nature A quintuple [GLP-1 + 4 other] receptor agonist drug that exceeds effects of the dual receptor (GLP-1 and GIP, tirzepatide) in the experimental model vs diabetes and obesity (in case you thought a dual receptor was max effect, as also seen with retatrutide, a triple pic.twitter.com/bvjCbj5Y6P - Eric Topol (@EricTopol) April 29, 2026 Journal reference: Liskiewicz, D., Novikoff, A., Khalil, A

3) Other prescription weight-loss medicines (some injectable, many oral) There are other weight-management medications with different mechanisms (some reduce fat absorption, some act centrally on appetite)

Shalev A, Holst JJ, Keller U