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acute effects Reduced administration Frequency: Once-weekly research administration protocols feasible Steady-State Pharmacology: Investigation of metabolic adaptations under sustained receptor activation Translational Relevance: Models clinically relevant long-acting formulation pharmacology Protease Stability: Semaglutide carries a DPP-4-resistant Aib8 substitution, while cagrilintide (an amylin analog, not a DPP-4 substrate) is stabilized by lipidation and albumin binding

[DOI] [PubMed] [Google Scholar] 15.Nijst T.Q., Wevers R.A., Schoonderwaldt H.C., Hommes O.R., De Haan A.F

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